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Page No 123:

Question 1:

Select the right match of endocrine gland and their hormone among the options given below
 

A. Pineal i. Epinephrine
B. Thyroid ii. Melatonin
C. Ovary iii. Estrogen
D. Adrenal medulla iv. Tetraiodothyronine

Options:
a. A-iv, B-ii, C-iii, D-i
b. A-ii, B-iv, C-i, D-iii
c. A-iv, B-ii, C-i, D-iii
d. A-ii, B-iv, C-iii, D-i

Answer:

Pineal gland secretes a hormone called melatonin which is involved in regulating biological rhythm of the body. Thyroid gland secretes a hormone called tetraiodothyronine which regulates metabolism of body. Ovary secretes estrogen which is responsible for growth and development of female sexual characteristics and reproductive organs. Adrenal medulla secretes hormone epinephrine which is released in response to any kind of fight or flight situation.

Hence, the correct answer is option D.

Page No 123:

Question 2:

2. Which of the following hormones is not secreted by anterior pituitary?
a. Growth hormone
b. Follicle stimulating hormone
c. Oxytocin
d. Adrenocorticotrophic hormone

Answer:

Hormones which are secreted by the pars distalis region of the pituitary are growth hormone (GH, prolactin (PRL), thyroid stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and follicle stimulating hormone (FSH). Pars distalis is also called anterior pituitary.
Pars nervosa is also known as posterior pituitary that stores and releases two hormones called oxytocin and vasopressin. These hormones are actually synthesized by hypothalamus and are transported to pars nervosa. 

Hence, the correct answer is option C.

Page No 123:

Question 3:

Mary is about to face an interview. But during the first five minutes before the interview she experiences sweating, increased rate of heart beat, respiration etc. Which of the following hormones are responsible for her restlessness?
a. Estrogen and progesterone
b. Oxytocin and vasopressin
c. Adrenaline and noradrenaline
d. Insulin and glucagon

Answer:

When Mary was about to face an interview, she was experiencing sweating, increased heart rate and respiration because adrenal gland released emergency hormones of fight or flight, i.e. adrenaline and nor-adrenaline which stimulate the breakdown of glycogen resulting in increasing concentration of glucose in blood.

Hence, the correct answer is option C.



Page No 124:

Question 4:

The steroid responsible for balance of water and electrolytes in our body is
a. insulin
b. melatonin
c. testosterone
d. aldosterone

Answer:

The steroid hormone aldosterone acts on the nephron for stimulating the reabsorption of Na+, water and excretion of Kions. This hormone is responsible for maintaining the balance of water and electrolytes in our body. It also regulates fluid volume, osmotic pressure and blood pressure. Insulin is a peptide hormone that regulates blood sugar level in the body.Testosterone is the male sex hormone that regulate spermatogenesis. Melatonin regulates 24 hour diurnal rhythm of the body.

Hence, the correct answer is option D.

Page No 124:

Question 5:

Thymosin is responsible for
a. raising the blood sugar level
b. raising the blood calcium level
c. differentiation of T lymphocytes
d. decrease in blood RBC

Answer:

Thymosin is responsible for differentiation of T-lymphocytes. It provides cell mediated immunity and promotes antibody production to provide humoral immunity.

Hence, the correct answer is option C.

Page No 124:

Question 6:

In the mechanism of action of a protein hormone, one of the second messengers is
a. cyclic AMP
b. insulin
c. T3
d. gastrin

Answer:

Insulin, Tand gastrin are the hormones secreted by pancreas, thyroid gland and stomach respectively. Thus, cyclic AMP is the correct option as it is one of the secondary messengers involved in the action of a protein hormone.

​Hence, the correct answer is option A. 

Page No 124:

Question 7:

Leydig cells produce a group of hormones called
a. androgens
b. estrogens
c. aldosterone
d. gonadotropins

Answer:

Leydig cells or interstitial cells are present in the interstitial spaces of testis. These produce a group of hormones called androgens. Testosterone is the main androgen that stimulates the growth and development of male secondary sex organs and regulates spermatogenesis. Gonadotropins are secreted by pituitary gland that stimulate gonadal activity. Aldosterone maintain electrolyte balance and estrogen stimulate female sex organs to produce ovum.

Hence, the correct answer is option A. 

Page No 124:

Question 8:

Corpus luteum secretes a hormone called
a. prolactin
b. progesterone
c. aldosterone
d. testosterone

Answer:

Corpus luteum secretes a hormone called progesterone. It supports pregnancy and also stimulate the development of duct system in the mammary gland for the milk production in females.

Hence, the correct answer is option B.

Page No 124:

Question 9:

Cortisol is secreted by
a. pancrease
b. thyroid
c. adrenal
d. thymus

Answer:

Cortisol is secreted from adrenal gland. The zona fasciculata region of adrenal cortex secretes hormone cortisol, corticosterone, cortisone. These hormones are involved in maintaining glucose homeostasis. Pancreas secretes insulin, thyroid gland secretes thyroxine and thymus gland secretes thymosin. 

Hence, the correct answer is option C.

Page No 124:

Question 10:

A hormone responsible for normal sleep-wake cycle is
a. epinephrine
b. gastrin
c. melatonin
d. insulin

Answer:

A hormone responsible for normal sleep-wake cycle is melatonin. Gastrin is secreted by the endocrine cells of stomach and help in secretion of HCl and pepsinogen. Epinephrine is secreted by adrenal gland which is a fight or flight hormone. Pancreas secretes hormone insulin that regulate blood glucose level.

Hence, the correct answer is option C.



Page No 125:

Question 11:

Hormones are called chemical signals that stimulate specific target tissues. Their action depends on the presence of receptors on the
respective target tissues. Which of the following is the correct location of the receptors in the case of protein hormones?
a. Extra cellular matrix
b. Blood
c. Plasma membrane
d. Nucleus

Answer:

Hormones act on the specific target tissue which possess hormone receptors. Protein hormones are hydrophilic in nature and can not cross the cell membrane. Receptors of these hormones are present on the plasma membrane of the cell on which it acts.

Hence, the correct answer is option C.

Page No 125:

Question 12:

Choose the correct option among the following options
 

Column I Column II
A. Epinephrine i. Stimulates muscle growth
B. Testosterone ii. Decrease in blood pressure
C. Glucagon iii. Breakdown of liver glycogen content
D. Atrial natriuretic factor iv. Increases heart beat
 
Options:
a. A-ii, B-i, C-iii, D-i
b. A-iv, B-i, C-iii, D-ii
c. A-i, B-ii, C-iii, D-iv
d. A-i, B-iv, C-ii, D-iii

Answer:

Epinephrine called stress hormone increases heartbeat. Testosterone helps in the growth of secondary sexual characters in men. For example muscle growth to make males muscular. Glucagon stimulates the breakdown of glycogen in liver. Atrial Natriuretic Factor (ANF) decreases blood pressure by vasodilation.
 
Hence, the correct answer is option B.

Page No 125:

Question 13:

Which of the following organs in mammals does not consist of a central incalcium balance in the human body?
a. Vitamin D
b. Parathyroid hormone
c. Thyrocalcitonin
d. Thymosin

Answer:

Thymosin hormone is secreted by thymus gland that plays a vital role in differentiation of T-lymphocytes. Thus, it has no role in regulation of blood calcium levels. Other hormones in the given options play an important role in calcium homeostasis in the body.

Hence, the correct answer is option D.

Page No 125:

Question 14:

Which of the following organs in mammals does not consist of a central meduallary region surrounded by a cortical region?
a. Ovary
b. Adrenal
c. Liver
d. Kidney

Answer:

Liver is the largest gland of the body. It is the only organ that does not consist of a central 'medullary' region surrounded by a cortical region.
Other three options, i.e. ovary, kidney and adrenal gland have a prominent medullary and cortical region.

Hence, the correct answer is option C.

Page No 125:

Question 15:

Which of the following conditions is not linked to deficiency of thyroid hormones?
a. Cretinism
b. Goitre
c. Myxedema
d. Exophthalmia

Answer:

Exophthalmia is a condition in which there is a bulging of the eye anteriorly out of the orbit. It is due to over secretion of thyroid hormone that result in the increase in the amount of lymphocytes in the eye and swelling due to excess amount of thyroid hormone. Cretinism, goitre and myxoedema are linked to thyroid deficiency.
 
Hence, the correct answer is option D.



Page No 126:

Question 1:

There are many endocrine glands in human body. Name the glands which is absent in male and the one absent in female.

Answer:

In males, a pair of testis is present in the scrotum. Testes is a primary sex organ and an endocrine gland that secretes the hormone testosterone. This gland is absent in females. In females, a pair of ovaries are present which is the primary sex organ and produces hormone estrogen and progesterone. These endocrine glands are absent in males.

Page No 126:

Question 2:

Which of the two adrenocortical layers, zona glomerulosa and zona reticularis lies outside enveloping the other?

Answer:

Zone glomerulosa is the outermost layer that envelops the other layer such as zona reticularis (inner layer) and zona fasciculata (middle layer).

Page No 126:

Question 3:

What is erythropoiesis? Which hormone stimulate it?

Answer:

The process of formation of RBCs is called erythropoiesis. Erythropoietin hormone secreted from juxtaglomerular apparatus of kidneys stimulate erythropoiesis.

Page No 126:

Question 4:

Name the only hormone secreted by pars intermedia of the pituitary gland.

Answer:

Pars intermedia of the pituitary gland secretes only one hormone known as melanocyte stimulating hormone (MSH). This hormone is responsible for skin darkening or skin pigmentation.

Page No 126:

Question 5:

Name the endocrine gland that produces calcitonin and mention the role played by this hormone.

Answer:

Calcitonin is a peptide hormone which is secreted by thyroid gland. It regulates or checks the calcium concentration in the blood by decreasing mobilisation from bones.

Page No 126:

Question 6:

Name the hormone that helps in cell - mediated immunity.

Answer:

Thymosin hormone plays an important role in cell-mediated immunity.

Page No 126:

Question 7:

What is the role of second messenger in the mechanism of protein hormone action?

Answer:

Peptide hormones are the derivatives of amino acids, polypeptides or proteins and are insoluble in lipids thus cannot enter the target cell. Hence, these act at the surface of target cell as primary messengers and create second messengers like cAMP affecting the functioning of target cells.

Page No 126:

Question 8:

State whether true or false:
a. Gastrointestinal tract, kidney and heart also produce hormones.
b. Pars distalis produces six trophic hormones.
c. B-lymphocytes provide cell-mediated immunity.
d. Insulin resistance results in a disease called diabetes mellitus.

Answer:

(a) True because gastrointestinal tract produces gastrin, secretin, cholecystokinin (CCK) and gastric inhibitory peptide (GIP). Kidney produces epinephrine, nor-epinephrine and corticoids. Heart produces ANF or atrial Natriuretic Factor.
(b) True because it produces gonadotropic hormone, adrenocorticotropic hormone, thyroid stimulating hormone, growth hormone, follicle stimulating hormone, prolactin etc.
(c) False because T-lymphocytes provide cell mediated immunity and B-lymphocytes provide humoral immunity.
(d) True because insulin is a hypoglycemic hormone that decreases blood sugar level.

Page No 126:

Question 9:

A patient complains of constant thirst, excessive passing of urine and low blood pressure. When the doctor checked the patient's blood glucose and blood insulin level, the level were normal or slightly low. The doctor diagnosed the condition as diabetes insipidus. But he decided to measure one more hormone in patients blood. Which hormone does the doctor intend to measure?

Answer:

The doctor wants to measure the level of ADH (anti-diuretic hormone) or vasopressin as low levels ADH can cause excessive urination, constant thirst and low blood pressure.

Page No 126:

Question 10:

Correct the following statements by replacing the term underlined.
a. Insulin is a steroid hormone.
b. TSH is secreted from the corpus luteum.
c. Tetraiodothyronine is an emergency hormone.
d. The pineal gland is located on the anterior part of the kidney.

Answer:

(a) Insulin is a  protein/peptide hormone.
(b) TSH is secreted from the anterior pituitary.
(c) Tetraiodothyronine is a maintenance hormone.
(d) The adrenal gland is located on the anterior part of the kidney.



Page No 127:

Question 11:

Rearrange the following hormones in Column I so as to match with their chemical nature in Column II.
 

Column I Column II  
a. Oxytocin i. Amino acid derivative (   )
b. Epinephrine ii. Steroid (   )
c. Progesterone iii. Protein (   )
d. Growth hormone iv. Peptide (   )

Answer:

  Column I   Column II
a. Oxytocin iv. Peptide
b. Epinephrine i. Amino acid derivative
c. Progesterone ii. Steroid
d. Growth hormone iii. Protein

Page No 127:

Question 1:

What is the role-played by luteinizing hormones in males and females respectively?

Answer:

In males, luteinizing hormone stimulates the synthesis and secretion of androgens from testes. This hormone stimulates the leydig cells present in the interstitial spaces of testes to produce testosterone. It is the hormone that is involved in growth and development of male accessory organs and spermatogenesis. In females, LH induces ovulation of fully mature follicles and release secondary oocyte under its influence. It also promotes the development of corpus luteum, formed from the remains of graafian follicles which secretes progesterone.

Page No 127:

Question 2:

What is the role of second messenger in hormone action?

Answer:

Hormones such as protein hormones cannot enter the target cell and interact with specific receptors located on the surface of the cell membranes of the target cell and forms a hormone-receptor complex. Thus they generate second messengers such as cyclic AMP (cAMP) on the inner side of the plasma membrane. These second messengers further carries out all the functions of hormone.

Page No 127:

Question 3:

On an educational trip to Uttaranchal, Ketki and her friends observe that many local people were having swollen necks. Please help Ketki and her friends to find out the solutions to the following questions.
a. Which probable disease are these people suffering from?
b. How is it caused?
c. What effect does this condition have on pregnancy?

Answer:

(a) People with swollen necks must be suffering from goitre which is the enlargement of thyroid gland. This condition occurs due to iodine deficiency in the body. 
(b) It is caused due to the deficiency of iodine in the diet. Iodine is very important for the production of thyroid hormones-Tand T4. 
(c) Iodine deficiency results in under-secretion of thyroid hormone and result in hypothyroidism. During pregnancy it can cause defective development and abnormalities in the growing baby that may lead to stunted growth (cretinism), mental retardation, low IQ etc.

Page No 127:

Question 4:

George comes on a vacation to India from US. The long journey disturbs his biological system and he suffers from jet lag. What is the cause of his discomfort?

Answer:

Jet lag is a temporary sleep problem that occurs due to the disruption of the body clock and affect the ones who travels different time zones.
Melatonin hormone is responsible for maintaining the body rhythms of sleep-wake cycle. After the sunsets, eyes perceive darkness and alert the hypothalamus to release melatonin  that promotes sleep, and in sunlight, it tells the hypothalamus to hold the release of melatonin. Thus, hypothalamus can not re-adjust to its schedule instantly and cause jet lag which takes several days to overcome this problem.

Page No 127:

Question 5:

Inflammatory responses can be controlled by a certain steroid. Name the steroid, its source and also its other important functions.

Answer:

Inflammatory response can be controlled by a steroid hormone called cortisol which is mainly a glucocorticoid. It is secreted by the middle zone of adrenal cortex called zona fasciculata. Cortisol affects carbohydrate metabolism, and metabolism of proteins and fats. It also stimulates gluconeogenesis, lipolysis and proteolysis. It is also a stress hormone as it modulates many changes in the body at the time of stress.

Page No 127:

Question 6:

Old people have weak immune system. What could be the reason?

Answer:

Thymus gland is an endocrine gland that secrets hormone thymosin which stimulates the development of immune system by differentiation of T-lymphocytes. In old people, thymus is degenerated, resulting in decreased production of thymosin. As a result, old people develops a weak immune system.

Page No 127:

Question 7:

What are the effects of hypothyroidism (observed during pregnancy) on the development and maturation of a growing baby?

Answer:

If a pregnant women is suffering from hypothyroidism there are chances of defective development of the baby in the womb. The growing baby may not develop properly, show mental retardation, stunted growth, abnormal skin development, low intelligence, deaf mutism etc.

Page No 127:

Question 8:

Mention the difference between hypothyroidism and hyperthyroidism.

Answer:

Hypothyroidism Hyperthyroidism
(i) This condition arises when there is less than normal secretion of thyroid hormone.
(ii) It reduces the metabolic rate of the body.
(iii) It occurs due to iodine deficiency in the body.
(iv) Symptoms include weight gain, muscle cramps, fatigue, dry hair/skin, decreased/irregular menstrual flow etc.
(v) In pregnant ladies, the baby might develop low IQ, cretinism (mental retardation), dry skin or skin abnormalities.
(i) This condition arises when there is more than normal secretion of thyroid hormone.
(ii) It increases the metabolic rate of the body.
(iii) It occurs due to the development of tumor or nodules in thyroid gland.
(iv) Symptoms include feeling hot, forgetfulness, sweating, increased heart rate, disturbed bowel movement etc.
(v) Person may develop exopthalmic goitre or Grave's disease.

 

Page No 127:

Question 9:

You have learnt that a characteristic feature of endocrine system is the presence of feed back loops. By this what is meant if hormone A stimulates gland ‘X’ to secrete hormone B, the production of ‘A’ could be modified when the level of B changes in our blood. An example is the relation between hormones LH and estrogen (E2). An old woman exhibits the following features. High levels of LH in blood but low levels of E2 in the blood. Another woman exhibits high level of LH in blood and also high level of E2 in the blood. Where is the defect in both these women? Provide suitable diagram to support this answer.

Answer:

LH or luteinizing hormone (A) is secreted by the pituitary gland. A stimulates the ovaries (X) to produce E2 . When the concentration of E2 increases in the blood it creates a negative feedback loop and reduces the synthesis of A.

In the case of first old woman, she has high levels of LH in the blood which should stimulate gland X to secrete more E2. Here she has low levels of E2 in the blood which signifies LH is not able to stimulate the ovaries to produce E2.

In the second case, she has high levels of LH in blood and also high level of E2 in the blood. High E2 should show negative feedback control decreasing the secretion of LH. The given situation signifies there is some defect in the negative feedback loop.




Page No 128:

Question 1:

A milkman is very upset one morning as his cow refuses to give any milk. The milkman’s wife gets the calf from the shed. On fondling by the calf, the cow gave sufficient milk. Describe the role of endocrine gland and pathway associated with this response?

Answer:

Milk secretion in mammals is stimulated by the hormone oxytocin which is released from neurohypophysis. When the calf sucks the cow's udder, it triggers the nerve impulses. Neurons in the Hypothalamic nuclei start to synthesize oxytocin. The concentration of oxytocin is increased within 1-2 minutes of udder stimulation.
Smooth muscles around the alveoli in the udder gets contracted and milk is released.
Udder (sucking stimulus) → Brain (Hypothalamus) → Neurohypophysis → Blood (oxytocin) → Udder (Smooth muscles) → Milk flow.

Page No 128:

Question 2:

A sample of urine was diagnosed to contain high content of glucose and ketone bodies. Based on this observation, answer the following:
(a) Which endocrine gland and hormone is related to this condition?
(b) Name the cells on which this hormone acts.
(c) What is the condition called and how can it be rectified?

Answer:

(a) An endocrine gland-pancreas and the hormone insulin secreted by it is related to this condition.
β-cells present in islets of langerhans in the pancreas secrete insulin. Insulin is a peptide hormone that plays a major role in regulating blood glucose level. When insulin is dysfunctional or not produced, then glucose uptake is hampered and thus glucose along with ketone bodies appear in urine and causes diabetes mellitus.

(b) Insulin hormone acts on the liver cells/hepatocytes and the adipocytes (cells of adipose tissues). Insulin increases the glucose uptake and utilization.

(c) The condition arises is prolonged hyperglycemia which leads to the disorder called diabetes mellitus. In the condition, glucose level in the blood rise and glucose is lost through urine. Diabetes can be treated or controlled by insulin therapy which lowers the blood glucose level.

Page No 128:

Question 3:

Calcium plays a very important role in the formation of bones. Write on the role of endocrine glands and hormones responsible for maintaining Calcium homeostasis.

Answer:

The movement of calcium ions between the body fluids and cells is known as calcium homeostasis. The endocrine glands responsible for this are thyroid and parathyroid glands that secrete calcitonin and parathyroid hormone (PTH) respectively.
(i) Parathyroid Glands - The chief cells of parathyroid glands secrete parathyroid hormone (PTH) which is involved in regulating calcium and phosphate balance between the blood and other tissues. It mobilises the release of calcium ions into the blood from bones. It also increase of calcium reabsorption by body organs like intestine and kidneys.
(ii) Thyroid Glands - It releases thyrocalcitonin hormone produced by parafollicular cells when the calcium levels in the blood are high. it suppreses the mobilisation of calcium ions from bones.

Page No 128:

Question 4:

Illustrate the differences between the mechanism of action of a protein and a steroid hormone.

Answer:


Peptide Hormone Action
 
Steroid Hormone Action
(i) Peptide hormones interact with membrane bound receptors.
(ii) They generates second messenger for further second action. (eg - cyclic AMP, IP3, Ca2+ etc.).
(iii) The second messengers affect cellular metabolism.
(iv) Example: insulin, glucagon, vasopressin etc.

(v) 















 
(i) Steroid hormones interact with intracellular receptors.
(ii) They do not generates second messengers.
(iii) They regulate gene expression or functions of chromosomes by the interaction of hormone receptor complex with the genome.
(iv) Example: cortisol, testosterone, estrogen and progesterone.

(v) 







 

Page No 128:

Question 5:

Hypothalamus is a super master endocrine gland. Elaborate.

Answer:

Hypothalamus is a very small but important part of the brain that is involved in endocrine, autonomic and behavioural functions. It consists of some neurosecreting cells called nuclei that produces hormones.
It produces two types of hormones:
(1) Releasing hormones (that stimulate the secretion of pituitary hormones).
(2) Inhibiting hormones (that inhibit the secretion of pituitary hormones).
Hypothalamus release major hormones that control the pituitary hormones. These are as follows:
(i) Adrenocorticotropic releasing hormone (ARH)- Regulates the secretion of ACTH from anterior pituitary.
(ii) Thyrotropin releasing hormone (TRH)- Regulates the pituitary gland for the secretion of TSH.
(iii) Growth hormone releasing hormone- Regulates the pituitary gland for the secretion of growth hormone.
(iv) Gonadotropin releasing hormone- Regulates the pituitary gland for the secretion of gonadotrophins.
(v) Prolactin releasing hormone- Regualtes the release of prolactin from anterior pituitary.
(vi) MSH releasing hormone- Regulates pars intermedia for the secretion of MSH (melanocyte stimulating hormone).
Hypothalamus is called the super master endocrine gland because it regulates the syntheses and secretion of pituitary gland hormones. Pituitary gland is a master gland as it regulates the synthesis and secretion of other endocrine glands.



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